Reproduction steps:
1. Open the attached "repro_IN-84092" project
2. Open the "Assets/Scenes/SampleScene.unity" Scene
3. In the "Assets" folder, select the "Character.psb" Prefab
4. In the Inspector, press the "Open Sprite Editor" button
5. In the Sprite Editor window overlay, press on the top-left dropdown and select "Skinning Editor"
6. Press on the most-left bone on the hand on the left
7. Change the "Depth" parameter to 100 and click "Apply"
8. In the Scene view, notice that the form of the hand on the left doesn't change
9. Now, in the Sprite Editor window, press on the most-right bone on the hand on the right
10. Change the "Depth" parameter to 100 and click "Apply"
11. Observe the Scene view

Expected result: The hand on the right is straight
Actual result: The hand on the right is twisted

Reproducible with: 2021.3.43f1, 2022.3.46f1, 6000.0.19f1

Reproducible on: Windows 10 (22H2)
Not reproducible on: No other environments tested

Notes:

• Reproducible in Play Mode and in the Player
• On 7.1.1, the hand is twisted even while the “Depth“ parameter of the bone is set to 0

Notes from dev:

• This issue is related to the depth (z position of the bones).
• Instead of modifying the depth of the bone in the Skinning Editor, you can also modify the z position of the bone directly in the Scene. (See the Scene - Bone Depth.mov video)