How to reproduce:
1. Open the user-attached project
2. Open the Game View
3. Make sure “Fullscreen on” is selected
4. Enter Play Mode
5. Interact with UI Elements in the Scene

Expected result: UI Elements respond to actions made
Actual result: UI Elements do not respond to actions made

Reproducible with: 2022.1.20f1, 2022.2.0b11, 2023.1.0a14
Couldn't test with: 2020.3.40f1, 2021.3.12f1 (No Full-Screen setting available)

Reproduced on: macOS Monterey 12.6 (Intel)

Notes:
- If the UI Elements disappear, select the Aspect Ration setting in the Game View and turn off the “Low-Resolution Aspect Ratios” setting
- User reported issue also happens in the build, but could not verify it as the builds always fail due to script errors regarding “CustomEditor”, and couldn’t fix
- The user reported a workaround that adding EventSystem into the Scene fixes the problem, the solution did not work when testing