To reproduce:

1. Download the attached project "rqa-project.zip" and open it in Unity
2. Open "New_Lobby" Scene
3. In Game View set Play Mode type to Fullscreen
4. Enter Play Mode
5. Click several times on the "< Leave" button
6. Observe that the "< Leave" button is responsive
7. Try clicking several times on the "< Close Lobby" button

Expected Result: Just as the "< Leave" button the "< Close Lobby" button is responsive
Actual Result: The "< Close Lobby" button is not responsive or the "< Leave" button is clicked instead

Notes:
- This issue is reproducible only on Editor
- If you slightly move the mouse and then try to click the "< Close Lobby" button then it becomes responsive

Reproduced on Unity 2022.1.0a16 and 2022.1.0b2
Could not check on Unity older versions cause the FullScreen Play Mode feature was implemented in 2022.1.0a16

IMPORTANT UPDATE:

This bug only repros when multiple monitors are connected with _different resolutions_ and the Fullscreen GameView is running on a different display than the Editor. Specifically, to repro the bug you must configure you environment as follows:
* Connect at least 1 secondary display that has a different resolution than the primary display
** The bug will not repro if all displays have the same resolution
* Run GameView on a different display than the Editor
** The bug will not repro if Fullscreen GameView is on the same display as Editor

Also, another Unity project is attached: "CC_UI.zip" It's a much smaller and simpiler project that'll repro the bug: the "Settings" button in the bottom-right won't "click" when running in the Fullscreen PlayMode environment described above.