Reproduction steps:
1. Open the attached project "ReproProj2"
2. Open the “/Assets/Scenes/SampleScene.unity” Scene
3. Switch to Android Platform
4. In the Build Settings window, select Development Build (File > Build Settings > Development Build)
5. Build and Run on Quest
6. Open the Memory Profiler and connect to the Quest
7. Take a capture when the screen is green
8. Take a capture when the screen is red
9. Select Compare Snapshots
10. Select the 2 Snapshots
11. Observe the difference of memory in Graphics

Expected result: The difference below 1 MB
Actual result: The difference is ~230-300 MB

Reproducible with: 2022.3.21f1
Not reproducible with: 2021.3.38f1, 6000.0.3f1
Fixed in: 2022.3.22f1

Reproducible on:
VLNQA00379, Oculus (Quest 2), Android 10, CPU: Snapdragon XR2, GPU: Adreno (TM) 650

Testing environment: Windows 10 Enterprise 21H2
Not reproducible on: No other environment tested

Workaround:
- Use Screen.SetResolution(16, 16, true);